Sensible Medicine

APRIL 14, 2024

Last week, the US FDA held a meeting to decide if a new surrogate endpoint (Minimal Residual Disease or MRD negativity) could be used to give more & faster drug approvals for patients with newly diagnosed multiple myeloma. Multiple myeloma drugs can cost $600,000 per year of treatment, but if MRD is permitted for drug approval, I suspect we will see a deluge of uncertain drugs added to the roster, and the costs per year per patient will swell to a million dollars or more.

Patient Safety 143

Patient Safety Academics Outcomes Wellness 143

Science Based Medicine

APRIL 14, 2024

Trying to limit pediatric COVID was literally the pandemic's worst sin for pro-infection doctors, warranting severe punishment. This is how desperately they wanted them infected. The post Dr. Vinay Prasad: It’s “Good” That Parents Who Want To Vaccinate Their Kids Against COVID Get Reported To Child Protective Services first appeared on Science-Based Medicine.

Pediatrics 132

Pediatrics 132

Dr. Smith's ECG Blog

APRIL 14, 2024

A 56 year old male with PMHx significant for hypertension had chest pain for several hours, then presented to the ED in the middle of the night. He reported chest pain that developed several hours prior to arrival and was 5/10 in intensity. The pain was located in the mid to left chest and developed after riding his bike. There was associated fatigue when symptoms developed and mild shortness of breath at onset of chest pain however that has since resolved.

EKG/ECG 96

EKG/ECG Ultrasounds EMS Wellness 96

Taming the SRU

APRIL 14, 2024

Hernias 101 A hernia is described as, “the abnormal protrusion of abdominal contents through a defect involving the normal confines of the abdominal compartments” (9). It often involves a portion of the intestine protruding through a weak point of the abdominal wall. The location and size of the hernia often determines the symptoms and complications that a patient will present with.

Ultrasounds 82

Ultrasounds Emergency Department Pediatrics Wellness 82

Pediatric Education

APRIL 14, 2024

Patient Presentation A 5-day-old female came to clinic for their routine health supervision visit after birth. The baby was a term infant born to a 31 year old G1P1 female without problems during the pregnancy or delivery. The baby was breastfed and was doing well. The infant was not jaundiced and was eliminating well. The pertinent physical exam showed a 3.148 kg infant (25% overall, down 5% from birthweight), length 50 cm (50%), head circumference 35 cm (50%).

Pediatrics 40

Pediatrics Wellness 40