Mon.Dec 11, 2023

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Do mRNA vaccines produce harmful “junk proteins” that “gunk up” the cell and cause unintended “off-target” immune responses?

Science Based Medicine

A new study is making the rounds in the antivax crankosphere. The study found that the modified mRNA used in the Pfizer vaccine can cause a frame shift (to be explained) that results in the production of proteins besides the intended spike protein. The findings are, as you probably guessed, a big nothingburger compared to how they are being spun. The post Do mRNA vaccines produce harmful “junk proteins” that “gunk up” the cell and cause unintended “off-target” immune responses?

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Occlusion myocardial infarction is a clinical diagnosis

Dr. Smith's ECG Blog

Occlusion myocardial infarction is a clinical diagnosis Written by Willy Frick (@Willyhfrick). Willy is a cardiology fellow with a keen interest in the ECG in OMI. A woman in her late 70s presented with left arm pain. The arm pain started the day prior when she was at the dentist's office for a root canal. Her systolic blood pressure at the dentist was over 200 mm Hg.

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ECG Pointers: STEMI Equivalents from the American College of Cardiology

EMDocs

Authors: Genevieve Pentecost, MD (@genpentecost, Emergency Medicine Resident, Washington University School of Medicine in St Louis) and Aaron Lacy, MD (@AaronLacyMD, Assistant Professor of Emergency Medicine, Washington University School of Medicine in St Louis) // Reviewed by: Jamie Santistevan, MD (EM Physician, Presbyterian Hospital, Albuquerque, NM); Alex Koyfman, MD (@EMHighAK); Brit Long, MD (@long_brit) Introduction Welcome back to ECG Pointers from emDOCS.

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In Medicine, it's hard to challenge prevailing ideas

Sensible Medicine

This one hits at the heart of my field—the ablation of atrial fibrillation. Current thinking holds that the way to ablate AF is to electrically isolate the muscle bundles going in and out of the pulmonary veins. Think of it as building an electric fence around the pulmonary veins. We use different energy sources to ablate the tissue. This is a picture I made in 2012.

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Adverse childhood experiences

Don't Forget the Bubbles

Adverse Childhood Experiences (or ACEs, for short) are no new thing, but only in recent decades have we come to realise the scope of their impact on children and the adults they become. ACEs can broadly be defined as traumatic events occurring before age eighteen. What counts as an ACE is open for interpretation, with the official domains liable to change.

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More Hospitals are Closing

ACEP Now

The wave of increasing hospital closures and service line cutbacks continues to sweep the U.S. A recent article documents 56 additional U.S. hospitals that are closing clinical departments or ending or reducing services. Cited are issues of “shoring up finances,” “staffing shortages,” or “focusing on more in-demand services” as driving forces. 1 This adds to the over 640 (mostly rural) hospitals that recently failed financial stress tests and are adjudged to be at imminent risk of closing. 2 Of

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Research Roundup (December 2023)

First 10 EM

Welcome back to another edition of the research roundup, where we discuss an eclectic collection of articles selected through the rigorous process of whatever I happened to find most interesting in my recent reading (with a couple suggestions from Dr. Casey Parker). The BroomeDocs podcast version can be found here: [link] Our poorly managed hospitals […] The post Research Roundup (December 2023) appeared first on First10EM.

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Plant-Based Soft Medical Robots

Medagadget

Researchers at the University of Waterloo in Canada have developed plant-based microrobots that are intended to pave the way for medical robots that can enter the body and perform tasks, such as obtaining a biopsy or performing a surgical procedure. The robots consist of a hydrogel material that is biocompatible and the composite contains cellulose nanoparticles derived from plants.

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Battling Diabetes on the Frontline: Innovative Interventions in Emergency and Rescue Services

Emergency Live

Cutting-edge strategies for diabetic patient care in emergency situations Diabetes, a chronic disease affecting millions worldwide, poses a significant challenge for emergency services. Managing diabetes in emergency situations requires specific knowledge and effective strategies to ensure timely and adequate treatment for diabetic patients, who may face acute complications like hypoglycemia or hyperglycemia under critical conditions. […] The post Battling Diabetes on the Frontline: Innova

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204. Temporal Arteritis and Whole Body MRIs

Board Bombs

This may come as a surprise to you, but whole body MRIs don't help in this condition. What's more surprising is that ESR is more helpful than MRI here. What? Listen and let's talk temporal arteritis- an uncommon, scary cause of headaches. Want to experience the greatest in board studying? Check out our interactive question bank podcast- the FIRST of its kind here.

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Shadow Heroes of Pearl Harbor: Frontline Medics and Rescuers

Emergency Live

Reflecting on the medical response and heroism during the attack on December 7, 1941 The Initial Impact and Immediate Response The attack on Pearl Harbor on December 7, 1941, remains one of the most tragic moments in United States history. The images of sinking ships and rising smoke from the harbor have become iconic symbols […] The post Shadow Heroes of Pearl Harbor: Frontline Medics and Rescuers appeared first on Emergency Live.

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Case Report: Pancreatitis Mimics STEMI

ACEP Now

Many conditions outside of acute coronary syndrome (ACS) mimic ST-elevation myocardial infarction (STEMI), but only a handful of cases have reported ST-elevations (STE) in the setting of pancreatic inflammation where underlying ACS was excluded. 1,2 While acute pancreatitis can involve electrocardiographic changes in up to 50 percent of cases, the exact mechanism causing STE remains unknown. 3,4 Patients with ST segment elevation in the absence of classic ACS symptoms presents a dilemma for emer

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Medicine between vocation and competence: a path towards more equitable care

Emergency Live

Reflections on the importance of compassionate and accessible healthcare for all The lost vocation of medicine Medicine, historically seen as a vocation and service to humanity, is gradually losing this essence. The profession now faces a paradigm where technical skills overshadow the sense of service and solidarity toward patients. This shift profoundly impacts the doctor-patient […] The post Medicine between vocation and competence: a path towards more equitable care appeared first on Em

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A Sobering Year for Emergency Departments and Their Patients

ACEP Now

The Emergency Department Benchmarking Alliance (EDBA) is a membership organization composed of high-performance emergency departments (EDs) that share a commitment to quality. The preliminary 2022 report contained performance measures for 938 EDs that managed more than 46 million patient visits, plus 222 additional freestanding EDs that served more than 4 million patients.

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Frontiers of Oncology in Emergency Care: Prehospital Cancer Management

Emergency Live

Innovation and challenges in the care of oncological patients in emergency situations Urgent Oncology: A New Frontier Emergency oncology has become a key field in cancer patient care. Emergency services are often the first contact point for oncological patients presenting with acute complications, making effective and timely management crucial. Complications Related to Oncological Treatments Complications […] The post Frontiers of Oncology in Emergency Care: Prehospital Cancer Management a

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Annals of B Pod: Social EM Corner- Suicide Related Behaviors

Taming the SRU

PATIENT PRESENTATION A young woman with a past medical history of major depressive disorder presented to the emergency room via EMS for a report of intentional ingestion of an unknown substance. EMS reported that she was vomiting profusely on their arrival to the scene but during transport became increasingly lethargic. She was given intranasal Narcan with no improvement in clinical condition.

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Hurricane Otis in Mexico: Response to Devastation and Loss of Life

Emergency Live

An in-depth analysis of rescue operations and their effects on the affected community The devastating impact of Hurricane Otis Hurricane Otis, a Category 5 storm, violently struck the Pacific coast of Mexico, leaving behind a trail of destruction and death. With winds reaching 165 mph, it particularly devastated the city of Acapulco, causing extensive damage […] The post Hurricane Otis in Mexico: Response to Devastation and Loss of Life appeared first on Emergency Live.

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2023 Critical Care Year in Review (Part 1)

PulmCCM

Thank you all for supporting PulmCCM by reading, sharing, and commenting since its relaunch in May. To those who have been able to contribute financially, I’m especially grateful. I hope you continue to find it valuable. Wishing you all a safe and happy holiday season! -Matt Read Dr. Jon-Emile Kenny’s other posts in this series here. Sepsis, infectious disease Managing septic shock with a restrictive-fluids approach (preferentially using vasopressors after a single liter crystalloid

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2023 Ski Season: Alpine Rescue and Accident Prevention

Emergency Live

From physical preparation to prevention of major accidents Intensive Preparation for the Ski Season With the arrival of the 2023 ski season, the italian National Alpine and Speleological Rescue Corps (CNSAS) is engaged in intensive preparation. Recently, in Solda (Bolzano province, Italy), a crucial course dedicated to alpine rescue was held in preparation for safety […] The post 2023 Ski Season: Alpine Rescue and Accident Prevention appeared first on Emergency Live.

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Which Sedatives Are Best for Managing Severe Agitation in the Emergency Department?

ACEP Now

Patients with severe agitation are frequently encountered in the emergency department (ED) setting. The first steps in the management of agitation are de-escalation and calming techniques, situational modifications, and, if needed, oral medications. Unfortunately, these techniques may be insufficient. Emergency departments can be crowded and chaotic, further exacerbating mental health issues.

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What Happened to Phenylephrine?

ACEP Now

In September, a surprising publication by the U.S. Food and Drug Administration regarding the efficacy of oral phenylephrine as a nasal decongestant, caused a ruckus. 1 This publication would not come as a surprise to those following the past 15 years of efforts by the research teams examining phenylephrine. While they conclude that phenylephrine lacks efficacy, there remain important limitations to the scope of this action.