The Bottom Line

JANUARY 9, 2025

Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis Ware. 2024.8772 Clinical Question In critically ill adult patients with sepsis does the administration of acetaminophen compared to placebo increase the number of days alive and free of organ support to day 28? doi:10.1001/jama.2024.8772

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Sepsis Administration 65

First 10 EM

JUNE 12, 2023

Can herbs cure sepsis?

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Sepsis EMS 136

First 10 EM

JULY 29, 2024

Gestalt for sepsis? 1) The endless emphasis on rushing to hit treatment targets in sepsis or otherwise and 2) the assumption that decision instruments must be better than basic clinical judgment. This paper hits two of my biggest pet peeves in medicine.

Sepsis 121

Sepsis 121

PulmCCM

JANUARY 6, 2025

In the past decade, so-called “sepsis alerts” came out of nowhere to become a ubiquitous and resource-intensive component of inpatient medical care. “Sepsis alerts” are automated notifications that flag patients who meet certain criteria compatible with severe infection discernible from the electronic medical record.

Sepsis 45

Sepsis Documentation/Coding Hospitals Outcomes 45

PulmCCM

JANUARY 23, 2025

Various new “sepsis tests” have come to market or will soon, claiming to solve the problem of diagnostic imprecision in the early management of suspected sepsis. The lack of a reliable diagnostic test or universally accepted criteria to diagnose sepsis leads to significant challenges in clinical practice and research.

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Sepsis Wellness Emergency Department Research 45

Taming the SRU

JULY 24, 2024

Early Physician Gestalt Versus Usual Screening Tools for the Prediction of Sepsis in Critically Ill Emergency Patients. Ann Emerg Med 2024 Background Sepsis remains an increasingly common emergency department condition that is tied to higher morbidity and mortality across the United States as well as the rest of the world.

Sepsis 105

Sepsis Resuscitation Emergency Department Wellness 105

Ken Grauer, MD

OCTOBER 10, 2024

. = Today's C ASE C ontinues: The patient was treated for sepsis. Figure-3: The ECG was repeated after beginning treatment for sepsis. Following treatment for sepsis — the patient improved clinically. Figure-4: Comparison of the repeat ECG with the initial ECG ( after treatment of sepsis ). What has happened?

EKG/ECG 425

EKG/ECG Sepsis Wellness 425

EM Literature of Note

SEPTEMBER 1, 2023

This is a short retrospective report evaluating, primarily, the Epic Sepsis Prediction Model, and the mode in which is deployed. The Epic SPM generates a “prediction of sepsis score”, calculated at 15 minute intervals, providing a continuous risk score for the development of sepsis.

Sepsis 107

Sepsis Administration Wellness 107

University of Maryland CC Project

MAY 31, 2025

Skip to content University of Maryland Home Clinical Pearls & Cases Menu Toggle Airway Mechanical Ventilation Medical Education Neuro Critical Care Procedures Pulmonary Statistics and Epidemiology Trauma Critical Care Ultrasound Core Content Lecture Series Menu Toggle Cardiovascular Gastrointestinal Hematology/Oncology Infectious Disease Mechanical (..)

Sepsis 40

Sepsis Infectious Diseases Ultrasounds Airway Management 40

Emergency Medicine Education

JUNE 29, 2025

Starting antibiotics in sepsis is always a clinical dilemma; however, timely administration is one of the few interventions clearly shown to reduce mortality in septic patients.

Administration 40

Administration Sepsis Infectious Diseases Hospitals 40

PulmCCM

SEPTEMBER 17, 2023

The Centers for Disease Control and Prevention formally called on hospitals to develop robust sepsis care programs to systematically identify and treat sepsis, track outcomes, and improve care delivery. ” What is that, a sepsis Stasi? Unlike strokes and STEMIs, sepsis has no gold standard for diagnosis.

CDC 98

CDC Sepsis Hospitals Documentation/Coding 98

The Skeptics' Guide to EM

JULY 27, 2024

Early Physician Gestalt Versus Usual Screening Tools for the Prediction of Sepsis in Critically Ill Emergency Patients. Background: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Thus, early identification of sepsis might not be as important as sometimes stated in guidelines.

Sepsis 98

Sepsis Outcomes Documentation/Coding Hospitals 98

RebelEM

MAY 27, 2025

Rethinking Antibiotic Duration in Sepsis The BALANCE Trial Current IDSA guidelines for sepsis recommend individualized durations of antibiotic. Trauma Read More Is 7 Days Enough? Infectious Disease Read More TNK vs tPA The ORIGINAL Trial The American Heart Association and the European Stroke Organization have.

Fractures 110

Fractures Infectious Diseases Head Injuries Sepsis 110

EM Ottawa

JUNE 12, 2023

Questions and Methods: Using a cohort and QI approach, to demonstrate the effectiveness of a multidisciplinary educational intervention and EHR tool to increase sepsis bundle compliance. Findings: Overall EHR tool use increased from 23.3

Sepsis 98

Sepsis Emergency Department 98

PulmCCM

NOVEMBER 11, 2024

Severe bleeding, limb ischemia, and sepsis with bacteremia were also increased in the Impella group, with the composite outcome of adverse events occurring four times more often in Impella patients (24% vs 6%). But while the number needed to save a life was 8, the number needed to harm in DanGer-Shock was 6. Patients in the Impella arm had 2.8

Shock 98

Shock Sepsis Outcomes Research 98

Don't Forget the Bubbles

JUNE 2, 2025

Reviewed by PICSTAR team Article 3: International Consensus Criteria for Paediatric Sepsis and Septic Shock Schlapbach LJ, Watson RS, Sorce LR, et al. International Consensus Criteria for Pediatric Sepsis and Septic Shock. This expert panel looked to revise global criteria for the diagnosis of sepsis and septic shock in children.

Sepsis 62

Sepsis Shock Outcomes Research 62

PulmCCM

DECEMBER 3, 2024

Maintaining a mean arterial pressure (MAP) of 65 mm Hg has been advised for patients with sepsis and other forms of vasodilatory shock. No patient subgroup clearly benefited from a higher MAP target (or was harmed by a lower MAP), including patients with sepsis, pre-existing hypertension, or higher organ failure scores.

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Sepsis Shock Outcomes Hospitals 75

The Trauma Pro

AUGUST 16, 2024

Bottom line: It’s so easy to go down the sepsis path with sick kids, especially those who can’t talk yet. Here’s the fifth law: A previously healthy child who is in arrest, or nearly so, is a victim of child abuse until proven otherwise. But healthy children tend to stay healthy, and don’t easily get sick to the point of physiologic collapse.

Pediatrics 203

Pediatrics Sepsis EMS 203

Taming the SRU

DECEMBER 17, 2024

There is substantial evidence that IV fluids can be beneficial in patients with sepsis complicated by hypotension and labor. Patients receiving maintenance fluids are hemodynamically stable, but they are unable to orally meet their daily fluid and electrolyte requirements.

Dehydration 98

Dehydration Fluid Resuscitation Resuscitation Administration 98

EMDocs

JANUARY 1, 2025

Guideline Updates: Corticosteroids in Sepsis, ARDS, Community-Acquired Pneumonia This post covers the SCCM guideline updates on steroids in sepsis, ARDS, and community-acquired pneumonia. Sameer Desai and Omar Abbas Ahmed Malik cover BP management in the patient with neurologic emergency.

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Sepsis EMS EKG/ECG Hospitals 74

Critical Care North Hampton

JUNE 12, 2025

Discover how the STAR program improved sepsis survivorship

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Sepsis Research 68

St. Emlyn

JUNE 5, 2024

St.Emlyn's - Emergency Medicine #FOAMed The latest St Emlyn's podcast with discussion about Bougies, cardiac arrest, trauma, sepsis, race and medicine and choosing with intention The post Podcast – April 2024 Monthly Round Up – Bougies, cardiac arrest, trauma, sepsis, race and medicine, and choosing with intention appeared first on (..)

Sepsis 74

Sepsis 74

EMDocs

JANUARY 11, 2025

Clinical exam: 2, 3, 9 Abdominal distension and tenderness Nausea and vomiting Stool present in the rectal vault Peritonitis may be accompanied by hemodynamic instability in the case of sepsis. 2-4, 6 If there is a concern for perforation or sepsis, surgical consultation, blood cultures, empiric antibiotics, and fluids are recommended.

EMS 94

EMS Sepsis Shock Fluid Resuscitation 94

EMCrit

MAY 15, 2025

Our first episode uses a simple case to act as touch-point for a discussion of resus nursing in the ED. EMCrit Project by Scott Weingart, MD FCCM.

Sepsis 87

Sepsis 87

Emergency Medicine Journal

MARCH 25, 2025

Association between time to antibiotic and mortality in patients with suspected sepsis in the emergency department: post hoc analysis of the 1-BED randomised clinical trial by Philippon et al 1 Topic: Sepsis Outcome rating: Game changer The importance of early antibiotic administration in sepsis is well recognised, yet the necessity of strict 1-hour (..)

Sepsis 52

Sepsis Emergency Department Administration Outcomes 52

Board Bombs

SEPTEMBER 10, 2023

We're covering what's important in sepsis care. Sepsis: burn the stopwatches. We're covering what's important in sepsis care. Sepsis: burn the stopwatches. Take a guess what we won't be covering. It begins with an L and ends in -actate. Want to experience the greatest in board studying? September 11th, 2023.

Burns 52

Burns Sepsis Administration Hospitals 52

Board Bombs

SEPTEMBER 10, 2023

We're covering what's important in sepsis care. Sepsis: burn the stopwatches. We're covering what's important in sepsis care. Sepsis: burn the stopwatches. Take a guess what we won't be covering. It begins with an L and ends in -actate. Want to experience the greatest in board studying? September 11th, 2023.

Burns 52

Burns Sepsis Administration Hospitals 52

PulmCCM

JUNE 3, 2024

Acetaminophen (paracetamol): Wikipedia Over the past 30 years, dozens of chemical compounds have been tested as therapies for sepsis. What if all the while, an effective sepsis treatment was hiding in plain sight right there on the PRN medication list?

Sepsis 52

Sepsis Outcomes Academics Hospitals 52

Mind The Bleep

APRIL 22, 2025

NaCl IV bolus Plot child length, weight and head circumference on the growth chart Ensure the correct growth cart is used.

Sepsis 52

Sepsis Dehydration Ultrasounds Shock 52

Dr. Smith's ECG Blog

JANUARY 2, 2025

She was managed for sepsis with antibiotics including azithromycin, had hypotension with arterial and central lines placed and pressors. I do not see OMI here and all trops were only minimally elevated, consistent with either chronic injury from cardiomyopathy or with acute injury from sepsis. She was intubated.

EKG/ECG 122

EKG/ECG Sepsis Wellness Documentation/Coding 122

Pediatric EM Morsels

MARCH 29, 2024

If the patient presents in metabolic crisis and the exact diagnosis is not known, ED providers can send additional labs to help expedite the work up by obtaining : Plasma amino acids, Acylcarnitine profile, and Urine organic acids Management Goal: we want to stop the metabolic crisis and convert anabolism Remember your ABCs and O MI Sugar for your (..)

Dehydration 300

Dehydration Pediatrics Sepsis EMS 300

PulmCCM

MAY 16, 2024

The FDA approved the first-ever AI-powered electronic medical record-based prediction model for sepsis: The Sepsis Immunoscore, by Prenosis. If you look under the hood, it suffers from the same fundamental limitation as all the rest: the lack of a reference standard (gold standard) for diagnosing sepsis.

Sepsis 52

Sepsis Operations Hospitals 52

PulmCCM

JUNE 5, 2025

For sepsis and septic shock, the committee suggested delivering up to 30 ml/kg of crystalloid at the time of presentation. In the C-EASIE trial, ~300 patients in the emergency departments at eight hospitals in Belgium with “sepsis” (high NEWS score plus suspected infection) got 1.5 All three are in China.

Sepsis 52

Sepsis Resuscitation Shock Emergency Department 52

Board Bombs

OCTOBER 29, 2023

In the Spirit of Halloween let's cover Pediatric Sepsis- the tricks of the trade and how to not miss infections, as well as what to know for the test. Peds Sepsis: Nightmare on Epi Street. Peds Sepsis: Nightmare on Epi Street. Want to experience the greatest in board studying? Cite this podcast as: Briggs, Blake.

Sepsis 52

Sepsis Pediatrics Wellness 52

Board Bombs

OCTOBER 29, 2023

In the Spirit of Halloween let's cover Pediatric Sepsis- the tricks of the trade and how to not miss infections, as well as what to know for the test. Peds Sepsis: Nightmare on Epi Street. Peds Sepsis: Nightmare on Epi Street. Want to experience the greatest in board studying? Cite this podcast as: Briggs, Blake.

Sepsis 52

Sepsis Pediatrics Wellness 52

The Bottom Line

JUNE 27, 2025

Journal of Hepatology Association of central capillary refill time with mortality in adult trauma patients: a secondary analysis of the crash-2 randomised controlled trial data Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine Dorsal Digital Nerve Block Versus Ultrasound-Guided Selective Peripheral Nerve Block for Finger Analgesia: (..)

Emergency Department 69

Emergency Department Emergency Nursing Resuscitation Pediatrics 69

Critical Care North Hampton

JUNE 26, 2025

Explore the TESTS trial: thymosin α1's impact on 28-day mortality in sepsis reveals safety, yet no significant mortality benefits.

Sepsis 61

Sepsis Research 61