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TXA in head injuries

Don't Forget the Bubbles

No, I don’t give TXA to kids with isolated head injuries We want to stop any clot breakdown to try and slow any potential bleeding. What about head injury , though? Along came the CRASH 3 trial, another huge study looking specifically at TXA in traumatic brain injury. She’s wheeled to radiology. Brakes off.

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Preperitoneal Packing Vs Angioembolization: Part 1

The Trauma Pro

If the patient can be stabilized to some degree, interventional radiology can be very helpful. Unfortunately, it’s generally not feasible to operatively fix the pelvis acutely, and external fixation has limited impact on ongoing hemorrhage. Unfortunately, access after hours involves some degree of time delay.

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SGEM #429: It’s CT Angio, Hi. I’m the Problem. It’s Me. For Pediatric Oropharyngeal Trauma

The Skeptics' Guide to EM

Excluded: Oropharyngeal trauma combined with other severe head injury or multisystem trauma, not primary research, non-English publication * Intervention: CTA * Comparison: No CTA * Outcome: radiologic and clinical outcomes including infection, injury to vasculature, cerebrovascular injury, and neurologic abnormalities.

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2347 Traumatic brain injury coagulopathy is associated with raised intracranial pressure, 7-day progression of haemorrhage and mortality

Emergency Medicine Journal

Admission ITBI coagulopathy is common and associated with head injury severity and radiological evidence of BCC. Several admission tests were good or excellent predictors of BCC (d-dimer AUROC 0.832, fibrinogen AUROC 0.745) and 7-day mortality (aPTT AUROC 0.781, FIBTEM CT AUROC 0.717).

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Episode 16: “Blood”

PHEM Cast

Priorities for the bleeding trauma patient must include: Minimum time to control of bleeding (tourniquets / haemostatics / knife / interventional radiology) Normothermia Appropriate choice of destination (knife / IR) ?

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Trauma Resuscitation Updates

RebelEM

Lancet 2019 [11] >12,000 Adults with TBI within 3hrs of injury, GCS ≤12 or any ICH on CT scan, and no major extracranial bleeding were eligible Patients randomized to TXA 1g over 10 min + 1g IV over 8hrs vs Placebo given within 8hrs of injury (Later amended to within 3hrs of injury) Patients randomized to TXA 1g over 10 min + 1g IV over 8hrs vs (..)

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The PROPHY-VAP Trial: Ceftriaxone to Prevent VAP in Patients with Acute Brain Injury

RebelEM

It is possible that the ceftriaxone altered baseline bacterial colonization within the respiratory tract, causing cultures to be negative despite positive clinical and radiological signs, leaving room for a false negative diagnosis. Bacterial colonization patterns in mechanically ventilated patients with traumatic and medical head injury.

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