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"Sepsis bundles": No good evidence of benefit

PulmCCM

SEP-1, the Centers for Medicare & Medicaid Services (CMS)’s much-maligned sepsis “quality” measure, was the brainchild of a small group of insiders conceived in the early- to mid-2000s. SEP-1 was pushed through without waiting for the outcomes of three ongoing multicenter trials testing goal-directed therapy for sepsis.

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SGEM#468: Wide Open Monocytes – Using MDW to Diagnose Sepsis

The Skeptics' Guide to EM

Monocyte distribution width (MDW) as a screening tool for early detecting sepsis: a systematic review and meta-analysis. Background: Rapid and accurate diagnosis of sepsis is critical, as early intervention can significantly reduce patient mortality. Reference: Agnello et al. His WBC is elevated at 23,000 with a left shift.

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Pre-Hospital Antibiotics in Sepsis?

RebelEM

Background: Sepsis remains one of the leading causes of morbidity and mortality. It is well-established that earlier recognition and treatment can lead to better outcome for these patients . Prehospital Administration of Broad-Spectrum Antibiotics for Sepsis Patients: A Systematic Review and Meta-Analysis. Health Sci Rep 2022.

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Sepsis alerts work! Just not in the patients who fire the alerts

PulmCCM

In the past decade, so-called “sepsis alerts” came out of nowhere to become a ubiquitous and resource-intensive component of inpatient medical care. “Sepsis alerts” are automated notifications that flag patients who meet certain criteria compatible with severe infection discernible from the electronic medical record.

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SGEM#448: More than A Feeling – Gestalt vs CDT for Predicting Sepsis

The Skeptics' Guide to EM

Early Physician Gestalt Versus Usual Screening Tools for the Prediction of Sepsis in Critically Ill Emergency Patients. Background: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. It is a medical emergency that requires prompt recognition and treatment to improve patient outcomes.

Sepsis 98
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CDC gives a nudge to hospitals on sepsis care

PulmCCM

The Centers for Disease Control and Prevention formally called on hospitals to develop robust sepsis care programs to systematically identify and treat sepsis, track outcomes, and improve care delivery. ” What is that, a sepsis Stasi? Unlike strokes and STEMIs, sepsis has no gold standard for diagnosis.

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Can acetaminophen improve outcomes in sepsis?

PulmCCM

Acetaminophen (paracetamol): Wikipedia Over the past 30 years, dozens of chemical compounds have been tested as therapies for sepsis. What if all the while, an effective sepsis treatment was hiding in plain sight right there on the PRN medication list?

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